AIDS virus "locked up": women are better HIV controllers than men

AIDS virus 'locked': women are better at controlling HIV than men

September 19, 2025

By Camille Gaubert THE Subscribers

HIV is formidable for its ability to hide in the DNA of host cells. But in women, these viral reservoirs are more often "locked" in inaccessible parts of their DNA than in men, concludes new research revealing the urgency of considering gender when treating the AIDS virus.

HIV-positive woman

Women's immune systems are more effective against infections, but make them more vulnerable to autoimmune diseases.

Photo by PHILIPPE LOPEZ / AFP

Faced with the AIDS virus, women under treatment are better at locking down the virus hidden in their cells than men, concludes a new study published in the journal Science Translational Medicine. A capacity that would come from their innate (first line) immune responses, which are stronger than those of men.

“Locked” viral reservoirs

HIV AIDS Sex

en_USEnglish