Brain tumor: CAR-T cells could even prevent recurrences

December 10, 2024

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American researchers have modified immune cells to precisely target brain tumors. In a new study, and to show them which way to go, the scientists integrated the equivalent of a postal code and a protein address into the lymphocytes. This dual identification shows promising results.

MRI result showing the presence of a glioblastoma.

Liz Hafalia/AP/SIPA

Transforming patients' lymphocytes—cells of the immune system—to target cancerous tumors is the principle of a cell therapy that has been developing considerably in recent years. These are called CAR-T cells. Their effectiveness had already been proven in previous research on leukemia, notably in 2019.

And more recently, it has been demonstrated on cancer cells in the brain. Indeed, last November, a publication in the journal Nature revealed astonishing results on brain tumors in children: neurological progress and a reduction in tumor size, or even his disappearance in one of the patients.

Lymphocytes CAR-T cells Glioblastoma The Lymphocytes Immune cells