Charcot's disease: shedding light on the origin of toxic proteins

Charcot's disease: shedding light on the origin of toxic proteins

February 18, 2026

By Marie Parra THE Subscribers

A new development has emerged in the search for a treatment for amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. Biologists from the CNRS (French National Centre for Scientific Research) have studied a genetic anomaly in one form of this incurable neurodegenerative disease. This anomaly could be the target of a promising therapeutic approach, already being used in other pathologies.

Illustration of the degradation of motor neurons, nerve cells involved in the control of voluntary movements.

Illustration of the degradation of motor neurons, nerve cells involved in the control of voluntary movements.

Photo by KATERYNA KON/SCIENCE PHOTO LIBRA / KKO / SCIENCE PHOTO LIBRARY VIA AFP

Charcot's disease is a rare condition affecting approximately 8,000 patients in France. It results in progressive paralysis, limb by limb, and eventually impairs the respiratory capacity of those affected. Life expectancy after diagnosis is very limited, and the risk factors for this disease are not clearly identified.

In one out of ten cases, the disease is familial, but in the other cases, it appears spontaneously, without doctors identifying any specific behavior or exposure. As a consequence of this condition, the motor neurons, the cells responsible for voluntary movement, deteriorate. But why?

Charcot's disease Neurodegenerative disease Neurons

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