ALS: sleep disorders precede the onset of motor disorders

Charcot's disease: sleep disorders precede the onset of motor disorders

February 17, 2025

By Enola Tissandie THE Subscribers

French and German researchers have shown the appearance of sleep disorders characteristic of Lou Gehrig's disease, well before its onset. A discovery that could allow for early diagnosis of the incurable disease, and an improvement in the quality of life of affected patients.

Mouse lumbar motor neuron

After treatment, the lumbar motor neuron of the mouse with ALS does not die, but researchers do not know whether it is functional.

Simon J Guillot, Daniel Beckett and Matei Bolborea

"It's a very difficult disease. Improving the quality of life of patients, that alone is already a lot.". A neuroendocrinologist at Inserm and at the biomedical research center of the University of Strasbourg, Matei Bolborea works on Charcot's disease.

With its scientific name "amyotrophic lateral sclerosis" (ALS), Lou Gehrig's disease is a neurodegenerative disease that is currently incurable, which causes the death of motor neurons and consequently progressive paralysis of the muscles involved in voluntary motor function. As the disease progresses, it eventually affects the muscles responsible for breathing, and induces sleep disorders (apnea, waking up, etc.). In the case of other neurodegenerative diseases, there are also sleep disorders that are part of the diagnostic elements (Parkinson's, Alzheimer's), which until now had not been studied in the case of ALS.

Charcot's disease Neurons Sleep disorders

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