"depriving-the-bacteria-of-this-protein-disarms-it":-a-promising-path-against-antibiotic-resistance

“Depriving the bacteria of this protein disarms it”: a promising avenue against antibiotic resistance

April 29, 2025

By Enola Tissandie THE Reading 5 min. Subscribers

A consortium of researchers from French institutions has filed two promising patents in the fight against antibiotic resistance. They highlight a protein capable of disarming any type of bacteria against the immune system, making it more effective.

Antibiotics are not automatic

The goal of antivirulence is no longer to kill bacteria en masse, but to block their ability to multiply in the body or to secrete toxins.

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Antibiotic resistance could kill nearly 40 million people by 2050, or nearly 2 million direct victims per year worldwide, according to a study published in the journal The LancetSo researchers are getting busy, trying to find solutions to avoid this grim scenario, while there is still time.

Led by Nalini Rama Rao, a research director at INRAE, scientists have identified a protein produced by all bacteria to resist the immune system of the infected host. The Mfd protein also increases the bacteria's ability to develop resistance. In a library of 5 million molecules, they found the molecule NM102, capable of binding to the Mfd protein and inhibiting its action.

Antibiotic resistance Antibiotics Protein Tuberculosis

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