"Eternal Pollutants": Do PFAS Affect Placental Health and Fetal Development?

“Forever Pollutants”: Do PFAS Affect Placental Health and Fetal Development?

March 3, 2025

By Astrid Saint Auguste THE Reading 7 min. Subscribers

The entire French population is likely exposed to PFAS, these extremely persistent pollutants that are also present during a crucial period of our existence: intrauterine life. What impact do these "eternal pollutants" have on fetal development? A French study on a sample of pregnant women provides the beginnings of an answer.

Colorized ultrasound image of a fetus at 3 months

Intrauterine life, a period of vulnerability to eternal pollutants.

CAVALLINI JAMES BSIPBSIP via AFP

PFAS, a class of synthetic compounds, are present in many everyday, technical, and professional manufactured objects. At the molecular level, they are chains of carbon atoms of varying length. The chemical industry manipulates the length of these chains, from which hydrogen atoms are removed and replaced by fluorine atoms. Since the carbon-fluorine bond is a very strong chemical bond in organic chemistry, it is this bond that determines the extreme persistence of PFAS in all "compartments" of the environment: water, soil, atmosphere, and organisms.

We are therefore exposed to them through the water we drink, the food we eat, and the air we breathe. What happens to a pregnant woman contaminated by these substances and to the baby she is carrying? Long-term epidemiological research involving a cohort of women and children living in the Grenoble region is examining the impact of PFAS on the placenta.

Perennial pollutants (PFAS) Perfluorinated compounds (PFAS) Fetus Placenta Exposome

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