This article is taken from the monthly Sciences et Avenir ndeg931, dated September 2024.
At each meal, GLP-1 is secreted into the blood by intestinal cells in response to the arrival of chyle, partially digested food from the stomach. It is a mobilization signal addressed to the body to absorb nutrients. The action of this peptide appeared local because of its rapid degradation, but it was found to be much more widespread. "In the 2000s, our research showed that before acting through the blood, it activates the endings of the vagus nerve in contact with the intestinal cells ", testifies Remy Burcelin, from the Institute of Metabolic and Cardiovascular Diseases, in Toulouse.
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