Human cancer and oyster herpesvirus: a common mechanism discovered

Human cancer and oyster herpesvirus: a common mechanism discovered

September 25, 2024

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Ifremer researchers have revealed that the age of oysters influences the survival of their offspring. More surprisingly, young individuals from older parents are more sensitive to herpesvirus. To explain this sensitivity, the scientists studied a mechanism involved in cell ageing. They then highlighted a process similar to that which makes cells cancerous. A discovery that opens up new avenues of research.

X-shaped chromosomes

Telomeres are the ends of chromosomes (in yellow). They protect the “coding” DNA.

NOBEASTSOFIERCE / Science Photo Library / DDJ / Science Photo Library through AFP

Often in animals, including humans, the age of the parents can have negative effects on the offspring. Individuals from older parents see their survival and performance reduced. For several years, scientists have believed that telomeres, the ends of chromosomes, integrate in one way or another the age of the parents, are transmitted to the descendants and predict their lower survival. Telomeres are markers of aging and also play a key role in the development of cancers", underlines Andreaz Dupoue, researcher in evolutionary ecophysiology at theYou can find out more about Ifremer by clicking here., during an interview for Science and Future.

With his team, he was interested in the reproductive aging of cupped oysters, Magallana gigas, and their sensitivity to herpesvirus. Their results reveal that oysters from older parents are more sensitive to this virus, OsHV1 by its scientific name. Beyond this observation, the scientists made another discovery: this viral infection triggers a mechanism similar to that involved in 90% cancers. Their results were published in the journal Science Advances.

Cellular aging Cancers Chromosome Telomeres Herpes virus

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