aging-related-inflammation-is-ultimately-not-universal

Aging-related inflammation is not universal after all

July 1, 2025

By Camille Gaubert THE Subscribers

Until now, a universal belief, age-related increases in inflammation are absent in indigenous populations, a new study shows. And unlike industrialized populations, where this phenomenon is still found, this age-related inflammation does not increase the risk of chronic diseases such as diabetes, cancer, or Alzheimer's.

In industrialized populations such as those in France, aging is accompanied by an increase in inflammation

In industrialized populations such as those in France, aging is accompanied by an increase in low-level inflammation in the body and an increased risk of chronic diseases such as cancer, Alzheimer's or cardiovascular diseases.

Photo by CRISTINA PEDRAZZINI / CPD / Science Photo Library via AFP

“ I'm 78 years old. The hardest part is my body. I can't go very far anymore. I can walk for two days, no more.. » This sentence, surprising for our industrialized populations in which even young people are few to consider walking two days in a row, was pronounced by Juan Gutierrez Rivero, a member of the Tsimane population (also called Chimani) of Bolivia on the BBC World Service. Like the Orang Asli of Malaysia, the Tsimane live far from cities and show very few of the deleterious markers of aging found in industrialized populations. Notably, they are not affected by the constant increase in inflammation that was previously thought to be a universal marker of aging, and very few by the chronic diseases linked to it, reports a study published in the journal Nature Aging.

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