NIH-Funded Scientists Discover Clues to Precancer and Tumor Biology

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Wednesday October 30, 2024

The Human Tumor Atlas Network initiative, part of the Cancer Moonshot (sm), has produced a collection of articles that highlight new findings.

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The Human Tumor Atlas Network aims to better understand tumors, their microenvironment and their molecular characteristics.NCI

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Many studies have provided new insights into the development and spread of cancer tumors, as well as their response to treatment. These 10 studies are from the Human Tumor Atlas Network (HTAN), Cancer Moonshot funded by the National Institutes of Health^(sm) The publication of the three-dimensional map of human tumors will take place on October 31, 2024. Nature magazines.

Several studies examine the impact of the tumor microenvironment on cancer resistance to treatment and disease spread. Three studies trace the progression of colorectal precancerous tissues to cancer, measuring multiple molecular-cellular events. The development of single-cell analysis technologies and platforms is described in several new HTAN publications. A research presentation, presented by W. Kimryn Rathmell, MD, PhD, director of the National Cancer Institute at NIH, and Dinah Singe, PhD, deputy director for scientific strategy and development at NCI, describes the history of HTAN, its progress, and its future.

HTAN was launched in 2018. It creates maps that show the molecular characteristics of tumors and their surrounding microenvironments as they change over time. Teams of researchers from across the country use different technologies and computational approaches to analyze tumors at the single-cell level. This comprehensive, publicly available resource aims to help researchers better understand how cancer progresses, develops, and prevents it. The initiative published the first tumor atlas in 2020 or 2021.

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Shannon Hughes, PhD, Division of Cancer Biology at the National Cancer Institute; Sean Hanlon, Ph.D. Center for Strategic Scientific Initiatives; Sudhir Shrivastava, Ph.D. Division of Cancer Prevention NCI

Studies

You can find the collection on our website. https://www.nature.com/collections/fihchcjehc.

The National Cancer Institute: NCI leads the National Cancer Program, NIH, in its efforts to reduce the prevalence of cancer and improve the lives of cancer patients and their families through cancer research, development of new interventions, and training and mentoring of new investigators. Please visit the NCI website for more information about cancer. cancer.gov Call the NCI Contact Center at 1-800-4CANCER (800-422-6237).

The National Institutes of Health: The NIH is the national medical research agency of the U.S. Department of Health and Human Services. It consists of 27 institutes and centers. The NIH, the national medical research agency, consists of 27 institutes and centers and is part of the U.S. Department of Health and Human Services. Visit the NIH for more information about its programs. www.nih.gov.

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