short-term or long-term memory: a matter of "molecular timers"

Short-term or long-term memory, a matter of "molecular timers"

November 27, 2025

By Camille Gaubert THE Subscribers

To safeguard a memory from being forgotten, the brain successively uses molecular timers to maintain it from the short to the long term, a study has discovered. Three of these timers, including one related to those involved in immune memory, have been identified.

Neurons in the hippocampus, the main area of the brain involved in memory (illustration)

Neurons in the hippocampus, the main area of the brain involved in memory (illustration)

Photo by KATERYNA KON/SCIENCE PHOTO LIBRA / KKO / SCIENCE PHOTO LIBRARY VIA AFP

“ We keep it, we keep it a little, we don't keep it"If our brains functioned in the hands of little characters in front of a control panel, like in a cartoon Vice versaThe one in charge of memories would likely be a minor bureaucrat armed with at least three types of markers. In reality, three proteins, veritable "molecular timers," have been identified by researchers as each responsible for marking memories to be retained in the short, medium, and long term. AshIl, the one involved in long-term memory retention, belongs to a family of proteins already known to scientists, which participate in the preservation of immune memory after an infection!

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