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Thursday July 11, 2024
Analysis of NIH-funded health record data shows that serious infections often occur after serious initial infections.
A colorized scanning electron microscope image of SARS-CoV-2 particles (blue) on a red blood cell isolated from a patient's samples.NIAID
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Researchers have found that the severity of infection caused by the COVID-19 virus tends to predict the same level of illness the second time around. Scientists also found that long COVID is more common after the first infection than subsequent reinfection. This study was funded by the National Institutes of Health (NIH), Researching COVID To Enhance Recovery.RESTOREInitiative is a publication that appears in Communication Medicine.
This analysis was based on data extracted from the electronic health records (EHRs) of more than 3.1 million Americans participating in the National COVID Cohort Collaborative.N3C). The researchers focused their attention on 212,984 people who reported reinfection. These individuals had been infected from March 1, 2020 to December 31, 2022, then experienced a secondary infection between March 20, 2023. The majority of participants (203,735) were infected with COVID-19 twice, while a few (478 ) have been infected with COVID-19. more than three times. COVID-19 vaccinesAlthough not available for the entire study period, correlations were found between a protective effect.
About 27 % people with severe cases, that is, those who were hospitalized for coronavirus infection, were also hospitalized for reinfection. Severe COVID cases were associated with older people and underlying health conditions. About 87 % people hospitalized with mild cases, but not the first time, also had mild reinfections.
Reinfection was defined as occurring at least two months after the first infection. The most common time they occurred was when the omicron variants were in circulation, which occurred between late 2021 and 2022. The increase in cases is likely due to waning immunity and increased exposure to the coronavirus, including its highly infectious variants.
The researchers also found that long COVID was more common after the first infection than subsequent reinfection. Long COVID The review defined COVID-19 as people who have long-term symptoms after an acute infection, including feeling tired or coughing or problems sleeping, thinking or breathing.
Researchers also found that rates lower than the recommended rate of AlbuminA higher level of , which is a protein produced by the liver, could indicate an increased risk of reinfection. This could suggest that lower albumin levels are a risk factor for reinfection. Scientists think this is an issue that deserves more attention. For example, they suggest trials testing whether nutritional interventions can prevent or reduce the severity of reinfection.
This study was funded by the National Institutes of Health initiative RESTORE . Additional support came from N3C Data EnclaveThe NIH National Center for Advancing Translational Sciences also supports the.
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David C. Goff, MD, PhD, senior scientific program director of the RECOVER Observational Consortium Steering Committee and director of the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute, part of the NIH, are available for an interview about this article.
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Hadley E, Yoo YJ, Patel S, et al. An N3C-RECOVER electronic health record (EHR)-based cohort study characterizes SARS-CoV-2 and Long-COVID. Commun Med. 2024; do I: 10.1038/s43856-024-00539-2.
HHS COVID Coordination: The work that is being done here is part of a larger project. National Action Plan for Research The government's response to the terrorist attacks is described in (PDF, 1.33 MB). Memorandum from the President directing the Secretary of the Department of Health and Human Services to fully and effectively respond to COVID. The plan, led by Assistant Secretary of Health Admiral Rachel Levine and her companion Service and support for the COVID-19 long-term impacts report The paper (PDF, 1.66 MB) lays the foundation for advances in the prevention, diagnosis and treatment of COVID in people with long-term symptoms.
The RECOVER program: The National Institutes of Health Researching CoVID to Enhance Recover (NIH-RECOVER) initiative brings together clinicians, researchers, caregivers, and patients with community members and other stakeholders to diagnose and treat COVID. RECOVER has created the largest and most diverse group of COVID participants ever. The RECOVER trials also test potential interventions in five symptom domains. Visit the website for more information. recoverCOVID.org.
The National Institutes of Health: NIH is the medical research agency of the United States Department of Health and Human Services. It includes 27 institutes and centers. The NIH, the National Medical Research Agency, is a component of the United States Department of Health and Human Services. It is responsible for conducting basic, translational and clinical medical research and studying causes, treatments and cures. Visit NIH for more information about its programs. www.nih.gov.
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