Researchers from St. Jude Children's Research Hospital in the United States have published a study in the journal Nature Communications, revealing a potential link between 22q11.2 deletion syndrome (more commonly known as DiGeorge syndrome or velo-cardio-facial syndrome) and a greater risk of developing schizophrenia (see box below).
22q11.2 deletion syndrome is a chromosomal abnormality affecting 1 in 2,148 births, making it the most common gene deletion (or suppression) in humans. It most often results in cardiac or facial malformations, developmental delay, and immunodeficiency. Most of the deletions that result from this syndrome involve the Tbx1 gene, which is involved in cardiac, facial, and parathyroid development.
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