What if some depressions were caused by excessive inflammation? The precise causes of this mental illness are difficult to pinpoint, perhaps because they could differ from one patient to another. A low rate of serotonin In some, a lack of noradrenaline or other neurotransmitters (gamma-aminobutyric acid, glutamate, etc.); in others…
Another possible explanation is inflammation: nearly a third of patients have chronic inflammation, with elevated levels of pro-inflammatory proteins, such as interleukin-6. Researchers from the British universities of Bristol and Cambridge, and University College London, tested this hypothesis by treating depression with immunotherapy that targeted these molecules responsible for inflammation. The results, published on May 20, 2026 in JAMA Psychiatry, show that this approach could be effective for some patients.
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